MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle.
Sci Rep
; 6: 32823, 2016 09 09.
Article
em En
| MEDLINE
| ID: mdl-27610602
ABSTRACT
The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction. To further understand the regulation of the restriction point, we extended a mathematical model of the Rb-E2F pathway to include members of the microRNA cluster miR-17-92. Our mathematical analysis shows that microRNAs play an essential role in fine-tuning and providing robustness to the switch. We also demonstrate how microRNA regulation can steer cells in or out of cancer states.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína do Retinoblastoma
/
MicroRNAs
/
Fatores de Transcrição E2F
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article