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Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
Chen, Yuqing; Tang, Qing; Xiao, Qian; Yang, LiJun; Hann, Swei S.
Afiliação
  • Chen Y; Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
  • Tang Q; Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
  • Xiao Q; Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
  • Yang L; Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
  • Hann SS; Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
J Cell Mol Med ; 21(2): 222-233, 2017 02.
Article em En | MEDLINE | ID: mdl-27620163

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Solanáceas / Proteínas Proto-Oncogênicas c-jun / MAP Quinases Reguladas por Sinal Extracelular / DNA (Citosina-5-)-Metiltransferases / Receptores de Prostaglandina E Subtipo EP4 / Terapia de Alvo Molecular / Neoplasias Pulmonares Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Solanáceas / Proteínas Proto-Oncogênicas c-jun / MAP Quinases Reguladas por Sinal Extracelular / DNA (Citosina-5-)-Metiltransferases / Receptores de Prostaglandina E Subtipo EP4 / Terapia de Alvo Molecular / Neoplasias Pulmonares Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article