Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer.

ABSTRACT

MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid ß oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.