Linking the Microbiota, Chronic Disease, and the Immune System.
Trends Endocrinol Metab
; 27(12): 831-843, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27623245
ABSTRACT
Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microbiota
/
Sistema Imunitário
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article