Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study.

Dopper, Elise G P; Chalos, Vicky; Ghariq, Eidrees; den Heijer, Tom; Hafkemeijer, Anne; Jiskoot, Lize C; de Koning, Inge; Seelaar, Harro; van Minkelen, Rick; van Osch, Matthias J P; Rombouts, Serge A R B; van Swieten, John C

Dopper, Elise G P; Chalos, Vicky; Ghariq, Eidrees; den Heijer, Tom; Hafkemeijer, Anne; Jiskoot, Lize C; de Koning, Inge; Seelaar, Harro; van Minkelen, Rick; van Osch, Matthias J P; Rombouts, Serge A R B; van Swieten, John C.

Afiliação

Dopper EG; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, VU Medical Center, Amsterdam, The Netherlands.
Chalos V; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ghariq E; C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
den Heijer T; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
Hafkemeijer A; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Methodology and Statistics, Institute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
Jiskoot LC; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neuropsychology, Erasmus Medical Center, Rotterdam, The Netherlands.
de Koning I; Department of Neuropsychology, Erasmus Medical Center, Rotterdam, The Netherlands.
Seelaar H; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
van Minkelen R; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
van Osch MJ; C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Rombouts SA; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Methodology and Statistics, Institute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
van Swieten JC; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands.

Neuroimage Clin ; 12: 460-5, 2016.

Article em En | MEDLINE | ID: mdl-27625986

Assuntos

Circulação Cerebrovascular/genética; Peptídeos e Proteínas de Sinalização Intercelular/genética; Mutação/genética; Proteínas tau/genética; Adulto; Idoso; Estudos Transversais; Feminino; Demência Frontotemporal/diagnóstico por imagem; Demência Frontotemporal/genética; Humanos; Estudos Longitudinais; Imageamento por Ressonância Magnética; Masculino; Pessoa de Meia-Idade; Testes Neuropsicológicos; Progranulinas; Marcadores de Spin; Estatística como Assunto; Adulto Jovem

Palavras-chave

AD, Alzheimer's disease; ASL, arterial spin labeling; Arterial spin labeling; BDI-II, Beck Depression inventory II (BDI-II); BNT, Boston Naming Test; CBF, cerebral blood flow; Cerebral blood flow; FDG-PET, positron emission tomography with 18F-fluorodeoxyglucose; FTD, frontotemporal dementia; Frontotemporal dementia; GRN, progranulin; LDST, Letter Digit Substitution Test; MAPT, microtubule-associated protein tau; MMSE, Mini-Mental State Examination; Presymptomatic; RAVLT, Rey Auditory Verbal Learning Test; SAT, Semantic Association Test; TMT, Trailmaking Test; VAT, Visual Association Test; WCST, Wisconsin Card Sorting Test

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Circulação Cerebrovascular / Proteínas tau / Peptídeos e Proteínas de Sinalização Intercelular / Mutação Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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