RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer.

Lou, Peipei; Li, Chunlian; Shi, Liang; Xia, Tian-Song; Zhou, Wenbin; Wu, Jing; Zhou, Xujie; Li, Xiaoxia; Wang, Ying; Wei, Ji-Fu; Ding, Qiang

Lou, Peipei; Li, Chunlian; Shi, Liang; Xia, Tian-Song; Zhou, Wenbin; Wu, Jing; Zhou, Xujie; Li, Xiaoxia; Wang, Ying; Wei, Ji-Fu; Ding, Qiang.

Afiliação

Lou P; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Li C; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Shi L; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Xia TS; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Zhou W; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Wu J; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Zhou X; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Li X; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Wang Y; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Wei JF; Research Division of Clinical Pharmacology, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.
Ding Q; Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, 210000, China.

Oncotarget ; 8(10): 16387-16400, 2017 Mar 07.

Article em En | MEDLINE | ID: mdl-27634883

Assuntos

Neoplasias da Mama/metabolismo; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/metabolismo; Receptores de Progesterona/metabolismo; Regiões 3' não Traduzidas/genética; Elementos Ricos em Adenilato e Uridilato/genética; Animais; Western Blotting; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Células MCF-7; Camundongos Endogâmicos NOD; Camundongos SCID; Microscopia de Fluorescência; Progesterona/farmacologia; Progestinas/farmacologia; Ligação Proteica; Interferência de RNA; Estabilidade de RNA/genética; RNA Mensageiro/genética; Proteínas de Ligação a RNA/genética; Receptores de Progesterona/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

RNPC1; breast cancer; mRNA stability; progesterone receptor; proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / RNA Mensageiro / Receptores de Progesterona / Proteínas de Ligação a RNA Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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