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Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.
Sardi, Janaína de Cássia Orlandi; Gullo, Fernanda Patrícia; Freires, Irlan Almeida; Pitangui, Nayla de Souza; Segalla, Maicon Petrônio; Fusco-Almeida, Ana Marisa; Rosalen, Pedro Luiz; Regasini, Luís Octávio; Mendes-Giannini, Maria José Soares.
Afiliação
  • Sardi JC; Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, SP14801-902, Brazil; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP13414-90, Brazil. Electronic addr
  • Gullo FP; Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, SP14801-902, Brazil.
  • Freires IA; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP13414-90, Brazil.
  • Pitangui NS; Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, SP14801-902, Brazil.
  • Segalla MP; Department of Biochemistry and Chemical Technology, Institute of Chemistry, UNESP-Univ Estadual Paulista, Araraquara, SP14800-060, Brazil.
  • Fusco-Almeida AM; Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, SP14801-902, Brazil.
  • Rosalen PL; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP13414-90, Brazil.
  • Regasini LO; Department of Biochemistry and Chemical Technology, Institute of Chemistry, UNESP-Univ Estadual Paulista, Araraquara, SP14800-060, Brazil; Department of Chemistry and Environmental Sciences, Institute of Biosciences, Letters and Exact Sciences, São José do Rio Preto, SP15054-000, Brazil.
  • Mendes-Giannini MJ; Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, SP14801-902, Brazil. Electronic address: gianninimj@gmail.com.
Diagn Microbiol Infect Dis ; 86(4): 387-391, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27638348
ABSTRACT
We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Cafeicos / Candida albicans / Fluconazol / Nistatina / Sinergismo Farmacológico / Ésteres / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Cafeicos / Candida albicans / Fluconazol / Nistatina / Sinergismo Farmacológico / Ésteres / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article