Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.

Scheraga, Rachel G; Thompson, Christopher; Tulapurkar, Mohan E; Nagarsekar, Ashish C; Cowan, Mark; Potla, Ratnakar; Sun, Junfeng; Cai, Rongman; Logun, Carolea; Shelhamer, James; Todd, Nevins W; Singh, Ishwar S; Luzina, Irina G; Atamas, Sergei P; Hasday, Jeffrey D

Scheraga, Rachel G; Thompson, Christopher; Tulapurkar, Mohan E; Nagarsekar, Ashish C; Cowan, Mark; Potla, Ratnakar; Sun, Junfeng; Cai, Rongman; Logun, Carolea; Shelhamer, James; Todd, Nevins W; Singh, Ishwar S; Luzina, Irina G; Atamas, Sergei P; Hasday, Jeffrey D.

Afiliação

Scheraga RG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Thompson C; Critical Care Section, National Heart, Lung, Blood Institute, Bethesda, Maryland.
Tulapurkar ME; Department of Biology, Loyola University of Maryland, Baltimore, Maryland.
Nagarsekar AC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Cowan M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Potla R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Sun J; Medicine and Research Services, Baltimore Veterans Affairs Medical Care System, Baltimore, Maryland.
Cai R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Logun C; Critical Care Section, National Heart, Lung, Blood Institute, Bethesda, Maryland.
Shelhamer J; Critical Care Section, National Heart, Lung, Blood Institute, Bethesda, Maryland.
Todd NW; Critical Care Section, National Heart, Lung, Blood Institute, Bethesda, Maryland.
Singh IS; Critical Care Section, National Heart, Lung, Blood Institute, Bethesda, Maryland.
Luzina IG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Atamas SP; Medicine and Research Services, Baltimore Veterans Affairs Medical Care System, Baltimore, Maryland.
Hasday JD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Am J Physiol Lung Cell Mol Physiol ; 311(5): L941-L955, 2016 Nov 01.

Article em En | MEDLINE | ID: mdl-27638903

Assuntos

Epitélio/metabolismo; Epitélio/patologia; Fator 1 de Crescimento de Fibroblastos/metabolismo; Resposta ao Choque Térmico; Lesão Pulmonar/patologia; Animais; Apoptose/genética; Sítios de Ligação; Linhagem Celular; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Células Epiteliais/metabolismo; Células Epiteliais/patologia; Fator 1 de Crescimento de Fibroblastos/genética; Regulação da Expressão Gênica; Proteínas de Choque Térmico HSP70/metabolismo; Fatores de Transcrição de Choque Térmico; Resposta ao Choque Térmico/genética; Humanos; Fibrose Pulmonar Idiopática/genética; Pulmão/metabolismo; Pulmão/patologia; Lesão Pulmonar/genética; Camundongos; Reação em Cadeia da Polimerase; Regiões Promotoras Genéticas/genética; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Cicatrização/genética

Palavras-chave

epithelial wound healing; fibroblast growth factor-1; heat shock; heat shock factor-1; idiopathic pulmonary fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 1 de Crescimento de Fibroblastos / Resposta ao Choque Térmico / Epitélio / Lesão Pulmonar Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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