A novel, sensitive and selective method of UPLC/MS-MS for rapid simultaneous determination of midodrine and its active metabolite desglymidodrine in human plasma: Application to support bioequivalence study in healthy human volunteers.

Patel, Daxesh P; Nair, Sneha; Suhagia, Bhanubhai N; Patel, Bhargav M

Patel, Daxesh P; Nair, Sneha; Suhagia, Bhanubhai N; Patel, Bhargav M.

Afiliação

Patel DP; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, United States.
Nair S; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, India.
Suhagia BN; Dharamsinh Desai University, Nadiad, Gujarat, India.
Patel BM; Department of Chemistry, St. Xavier's College, Navrangpura, Ahmedabad 380009, India. Electronic address: bhargavp1001@gmail.com.

J Pharm Biomed Anal ; 131: 355-363, 2016 Nov 30.

Article em En | MEDLINE | ID: mdl-27639073

Assuntos

Midodrina/análogos & derivados; Midodrina/sangue; Espectrometria de Massas em Tandem/métodos; Cromatografia Líquida de Alta Pressão/métodos; Cromatografia Líquida de Alta Pressão/normas; Estudos Cross-Over; Humanos; Midodrina/análise; Espectrometria de Massas em Tandem/normas; Equivalência Terapêutica; Fatores de Tempo

Palavras-chave

Desglymidodrine; High throughput; Incurred sample reanalysis; Midodrine; Sensitive; UPLCMS/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrometria de Massas em Tandem / Midodrina Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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