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Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Sykes, David B; Kfoury, Youmna S; Mercier, François E; Wawer, Mathias J; Law, Jason M; Haynes, Mark K; Lewis, Timothy A; Schajnovitz, Amir; Jain, Esha; Lee, Dongjun; Meyer, Hanna; Pierce, Kerry A; Tolliday, Nicola J; Waller, Anna; Ferrara, Steven J; Eheim, Ashley L; Stoeckigt, Detlef; Maxcy, Katrina L; Cobert, Julien M; Bachand, Jacqueline; Szekely, Brian A; Mukherjee, Siddhartha; Sklar, Larry A; Kotz, Joanne D; Clish, Clary B; Sadreyev, Ruslan I; Clemons, Paul A; Janzer, Andreas; Schreiber, Stuart L; Scadden, David T.
Afiliação
  • Sykes DB; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02
  • Kfoury YS; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  • Mercier FE; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  • Wawer MJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Law JM; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Haynes MK; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA.
  • Lewis TA; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Schajnovitz A; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  • Jain E; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Lee D; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  • Meyer H; Bayer Pharma AG, Berlin 13353, Germany.
  • Pierce KA; Metabolite Profiling Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Tolliday NJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Waller A; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA.
  • Ferrara SJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Eheim AL; Bayer Pharma AG, Berlin 13353, Germany.
  • Stoeckigt D; Bayer Pharma AG, Berlin 13353, Germany.
  • Maxcy KL; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Cobert JM; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Bachand J; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Szekely BA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Mukherjee S; Irving Cancer Research Center, Columbia University School of Medicine, New York, NY 10032, USA.
  • Sklar LA; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA.
  • Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Clish CB; Metabolite Profiling Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Sadreyev RI; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Clemons PA; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Janzer A; Bayer Pharma AG, Berlin 13353, Germany.
  • Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Cambridge, MA 02138, USA.
  • Scadden DT; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02
Cell ; 167(1): 171-186.e15, 2016 Sep 22.
Article em En | MEDLINE | ID: mdl-27641501
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Terapia de Alvo Molecular / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Terapia de Alvo Molecular / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article