Synthesis and biological evaluation of new Rh (I) complexes with sulfonamide derivatives.
Anticancer Res
; 9(3): 781-5, 1989.
Article
em En
| MEDLINE
| ID: mdl-2764523
ABSTRACT
New rhodium(I) complexes, belonging to the general structure [Rh(CO)2(L)], where L were sulfonamide derivatives, were synthesized and characterized by chemical analysis and IR determinations. These complexes were assayed as cytostatic and antitumour agents in vitro against KB cells and in vivo against P388, Ehrich ascites and advanced B16 melanoma. Assays against three Trypanosoma strains were also performed. Among the new compounds, the [Rh(CO)2-(sulfamethoxydiazine)] appeared to be active in all biological systems without showing evident nephrotoxicity. Relationships between biological activity and pi electronic charge localization on N atom of the ligand amidic group were also discussed.
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Base de dados:
MEDLINE
Assunto principal:
Ródio
/
Sulfonamidas
/
Tripanossomicidas
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article