PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric ß-carboline.
Bioorg Med Chem Lett
; 26(20): 4884-4887, 2016 10 15.
Article
em En
| MEDLINE
| ID: mdl-27650927
ABSTRACT
Dimeric ß-carbolines are cytotoxic against multiple NSCLC cell lines, and we report herein our preliminary studies on the mechanism of action of these dimeric structures. Dimeric ß-carboline 1, which is more potent than the corresponding monomer in NSCLC cell lines, is a lysosomotropic agent that inhibits autophagy and mediates cell death by apoptosis, upregulating the pro-apoptotic BH3-only protein PUMA (p53 upregulated modulator of apoptosis) in a dose dependent manner.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
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Proteínas Proto-Oncogênicas
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Apoptose
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Carcinoma Pulmonar de Células não Pequenas
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Proteínas Reguladoras de Apoptose
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article