Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells.

Catena, Valeria; Bruno, Tiziana; De Nicola, Francesca; Goeman, Frauke; Pallocca, Matteo; Iezzi, Simona; Sorino, Cristina; Cigliana, Giovanni; Floridi, Aristide; Blandino, Giovanni; Fanciulli, Maurizio

Catena, Valeria; Bruno, Tiziana; De Nicola, Francesca; Goeman, Frauke; Pallocca, Matteo; Iezzi, Simona; Sorino, Cristina; Cigliana, Giovanni; Floridi, Aristide; Blandino, Giovanni; Fanciulli, Maurizio.

Afiliação

Catena V; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Bruno T; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
De Nicola F; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Goeman F; Epigenetic, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Pallocca M; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Iezzi S; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Sorino C; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Cigliana G; Clinical Pathology Laboratories, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Floridi A; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Blandino G; Epigenetic, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.
Fanciulli M; SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, 00144, Rome, Italy.

Oncotarget ; 7(43): 70546-70558, 2016 Oct 25.

Article em En | MEDLINE | ID: mdl-27655709

Assuntos

Retículo Endoplasmático; Homeostase/genética; Peptídeos e Proteínas de Sinalização Intracelular/genética; Animais; Antineoplásicos/farmacologia; Bortezomib/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/genética; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Estresse do Retículo Endoplasmático/genética; Perfilação da Expressão Gênica/métodos; Regulação Neoplásica da Expressão Gênica; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Camundongos Transgênicos; Mieloma Múltiplo/genética; Mieloma Múltiplo/metabolismo; Mieloma Múltiplo/patologia; Interferência de RNA

Palavras-chave

ER stress; deptor; homeostasis; multiple myeloma; transcription

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos e Proteínas de Sinalização Intracelular / Retículo Endoplasmático / Homeostase Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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