A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus Genotypes.
J Infect Dis
; 214(10): 1487-1491, 2016 11 15.
Article
em En
| MEDLINE
| ID: mdl-27655868
ABSTRACT
Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden. There are 3 CHIKV genotypes Asian, West African, and Eastern/Central/South African. No licensed CHIKV vaccine is available, and whether the antibody response elicited by one genotype can neutralize heterologous genotypes is unclear. We assessed neutralizing antibody (NAb) responses of volunteers in a phase 1 study of a CHIKV vaccine against 9 viral strains representing all 3 genotypes. Minimal differences in vaccine-elicited NAb responses were observed among genotypes, suggesting that vaccination with a single CHIKV strain can elicit cross-protective NAbs against all 3 genotypes.
Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vírus Chikungunya
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Reações Cruzadas
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Anticorpos Neutralizantes
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Vacinas de Partículas Semelhantes a Vírus
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Febre de Chikungunya
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Genótipo
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Anticorpos Antivirais
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article