Protecting Triazabutadienes To Afford Acid Resistance.
Chembiochem
; 17(23): 2220-2222, 2016 12 02.
Article
em En
| MEDLINE
| ID: mdl-27662242
ABSTRACT
Recent work on triazabutadienes has shown that they have the ability to release aryl diazonium ions under exceptionally mild acidic conditions. There are instances that require that this release be prevented or minimized. Accordingly, a base-labile protection strategy for the triazabutadiene is presented. It affords enhanced synthetic and practical utility of the triazabutadiene. The effects of steric and electronic factors in the rate of removal are discussed, and the triazabutadiene protection is shown to be compatible with the traditional acid-labile protection strategy used in solid phase peptide synthesis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos
/
Butadienos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article