Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.
Obesity (Silver Spring)
; 24(11): 2407-2413, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27663718
ABSTRACT
OBJECTIVE:
Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined.METHODS:
Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos.RESULTS:
The C-allele (frequency = 26%) of rs2943650 was significantly associated with higher BF% overall (ß = 0.34 ± 0.11% per allele; P = 0.002) and in women (ß = 0.41 ± 0.14% per C-allele; P = 0.003), but not in men (ß = 0.28 ± 0.18% per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF% was stronger in Hispanic/Latino women than that previously reported in European women (ß = 0.054 ± 0.018SD vs. ß = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF%-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05).CONCLUSIONS:
This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Hispânico ou Latino
/
Adiposidade
/
Proteínas Substratos do Receptor de Insulina
/
Metaboloma
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article