Novel benzoquinoline derivatives via unpredicted condensation of ethyl propiolate and naphthylamines: Synthesis and topoisomerase inhibition activity.
Bioorg Med Chem Lett
; 26(20): 4875-4878, 2016 10 15.
Article
em En
| MEDLINE
| ID: mdl-27665377
ABSTRACT
An unpredicted condensation of naphthylamine with two molecules of ethyl propiolate yields directly carbethoxy benzoquinoline in high yield. Some benzoquinoline carboxamide derivatives with protonatable side chains were then synthesized and evaluated for antiproliferative activity on human tumor cell lines. The most active compound (7a) demonstrated to intercalate into DNA and to inhibit the relaxation activity mediated by topoisomerase II.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Quinolinas
/
Alcinos
/
Inibidores da Topoisomerase II
/
Aminas
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article