Efficacy of Pre- and Post-Treatment by Topical Formulations Containing Dissolved and Suspended Silybum marianum against UVB-Induced Oxidative Stress in Guinea Pig and on HaCaT Keratinocytes.

Fehér, Pálma; Ujhelyi, Zoltán; Váradi, Judit; Fenyvesi, Ferenc; Róka, Eszter; Juhász, Béla; Varga, Balázs; Bombicz, Mariann; Priksz, Dániel; Bácskay, Ildikó; Vecsernyés, Miklós

Fehér, Pálma; Ujhelyi, Zoltán; Váradi, Judit; Fenyvesi, Ferenc; Róka, Eszter; Juhász, Béla; Varga, Balázs; Bombicz, Mariann; Priksz, Dániel; Bácskay, Ildikó; Vecsernyés, Miklós.

Afiliação

Fehér P; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. feher.palma@pharm.unideb.hu.
Ujhelyi Z; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. ujhelyi.zoltan@pharm.unideb.hu.
Váradi J; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. varadi.judit@pharm.unideb.hu.
Fenyvesi F; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. fenyvesi.ferenc@pharm.unideb.hu.
Róka E; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. roka.eszter@pharm.unideb.hu.
Juhász B; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. juhasz.bela@pharm.unideb.hu.
Varga B; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. varga.balazs@pharm.unideb.hu.
Bombicz M; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. bombicz.mariann@pharm.unideb.hu.
Priksz D; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. priksz.daniel@pharm.unideb.hu.
Bácskay I; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. bacskay.ildiko@pharm.unideb.hu.
Vecsernyés M; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary. vecsernyes.miklos@pharm.unideb.hu.

Molecules ; 21(10)2016 Sep 22.

Article em En | MEDLINE | ID: mdl-27669200

Assuntos

Queratinócitos/efeitos dos fármacos; Queratinócitos/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/efeitos da radiação; Silimarina/química; Silimarina/farmacologia; Raios Ultravioleta; Animais; Antioxidantes/química; Antioxidantes/farmacologia; Sobrevivência Celular/efeitos dos fármacos; Composição de Medicamentos; Ativação Enzimática/efeitos dos fármacos; Glutationa/metabolismo; Glutationa Peroxidase/metabolismo; Cobaias; Heme Oxigenase-1/metabolismo; Humanos; Peroxidação de Lipídeos/efeitos dos fármacos; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Solubilidade; Superóxido Dismutase/metabolismo

Palavras-chave

HO-1 enzyme; UVB-induced oxidative stress; antioxidants; silymarin; sucrose esters; topical formulations; transcutol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silimarina / Raios Ultravioleta / Queratinócitos / Estresse Oxidativo Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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