[Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin]. / Hypertension artérielle pulmonaire, moelle osseuse, précurseurs endothéliaux et sérotonine.
Biol Aujourdhui
; 210(2): 79-88, 2016.
Article
em Fr
| MEDLINE
| ID: mdl-27687599
ABSTRACT
Serotonin and bone-marrow-derived stem cells participate together in triggering pulmonary hypertension. Our work has shown that the absence of 5-HT2B receptors generates permanent changes in the composition of the blood and bone-marrow in the myeloid lineages, particularly in endothelial cell progenitors. The initial functions of 5-HT2B receptors in pulmonary arterial hypertension (PAH) are restricted to bone-marrow cells. They contribute to the differentiation/proliferation/mobilization of endothelial progenitor cells from the bone-marrow. Those bone-marrow-derived cells have a critical role in the development of pulmonary hypertension and pulmonary vascular remodeling. These data indicate that bone-marrow derived endothelial progenitors play a key role in the pathogenesis of PAH and suggest that interactions involving serotonin and bone morphogenic protein type 2 receptor (BMPR2) could take place at the level of the bone-marrow.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Medula Óssea
/
Serotonina
/
Células Endoteliais
/
Hipertensão Pulmonar
Limite:
Animals
/
Humans
Idioma:
Fr
Ano de publicação:
2016
Tipo de documento:
Article