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Preclinical study investigating the potential of low-dose-rate brachytherapy with 32P stents for the prevention of restenosis of paranasal neo-ostia.
Oestreicher, Elmar; Bartsch, Harald; Mayr, Doris; Schubert, Mario; Weber, Barbara; Kneschaurek, Peter; Assmann, Walter; Sroka, Ronald; Betz, Christian Stephan.
Afiliação
  • Oestreicher E; Department of Otorhinolaryngology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Bartsch H; Institute of Pathology, Ludwig Maximilian University, Munich, Germany.
  • Mayr D; Institute of Pathology, Ludwig Maximilian University, Munich, Germany.
  • Schubert M; Department of Medical Physics, Ludwig Maximilian University, Garching, Germany.
  • Weber B; Department of Otorhinolaryngology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Kneschaurek P; Department of Radiotherapy and Radiation Oncology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Assmann W; Department of Medical Physics, Ludwig Maximilian University, Garching, Germany.
  • Sroka R; Laser Research Laboratory, LIFE Centre, Klinikum der Universität München, Munich, Germany; Department of Urology, Klinikum der Universität München, Munich, Germany.
  • Betz CS; Laser Research Laboratory, LIFE Centre, Klinikum der Universität München, Munich, Germany; Department of Otorhinolaryngology, Klinikum der Universität München, Munich, Germany. Electronic address: christian.betz@med.uni-muenchen.de.
Brachytherapy ; 16(1): 207-214, 2017.
Article em En | MEDLINE | ID: mdl-27693170
PURPOSE: Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model. METHODS AND MATERIALS: In 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups. RESULTS: After 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group. CONCLUSIONS: Low-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Seios Paranasais / Radioisótopos de Fósforo / Complicações Pós-Operatórias / Braquiterapia / Stents / Constrição Patológica / Seio Maxilar Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Seios Paranasais / Radioisótopos de Fósforo / Complicações Pós-Operatórias / Braquiterapia / Stents / Constrição Patológica / Seio Maxilar Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article