Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism.
Drug Discov Today
; 22(2): 366-376, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27693711
ABSTRACT
Pharmacogenomics investigates DNA and RNA variations in the human genome related to drug responses. Cytochrome P450 (CYP) is a supergene family of drug-metabolizing enzymes responsible for the metabolism of approximately 90% of human drugs. Among the major CYP isoforms, the CYP2C subfamily is of clinical significance because it metabolizes approximately 20% of clinically administrated drugs and represents several variant alleles leading to adverse drug reactions or altering drug efficacy. Here, we review recent progress on understanding the interindividual variability of the CYP2C members and the functional and clinical impact on drug metabolism. We summarize current advances in the molecular modeling of CYP2C polymorphisms and discuss the structural bases and molecular mechanisms of amino acid variants of CYP2C members that affect drug metabolism.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
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Substituição de Aminoácidos
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Sistema Enzimático do Citocromo P-450
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article