The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells.
Stem Cell Rev Rep
; 12(6): 621-633, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27696271
ABSTRACT
Regulated self-consumption, also known as autophagy, is an evolutionary conserved process that degrades cellular components by directing them to the lysosomal compartment of eukaryotic cells. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining and remodeling cellular homeostasis during normal cellular and tissue development. Recent studies have demonstrated that autophagy is necessary for the maintenance of cellular stemness and for a number of differentiation processes, including the lineage determination of mesenchymal stem cells. These are multipotent progenitor cells with self-renewal capacities that can give rise to a subset of tissues and thus hold a consistent potential in regenerative medicine. Here, we review the current literature on the complex liaison between autophagy induced by various extra- or intracellular stimuli and the molecular targets that affect mesenchymal stem cells proliferation and differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Diferenciação Celular
/
Células-Tronco Pluripotentes
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Células-Tronco Mesenquimais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article