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Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities.
Subudhi, Sumit K; Aparicio, Ana; Gao, Jianjun; Zurita, Amado J; Araujo, John C; Logothetis, Christopher J; Tahir, Salahaldin A; Korivi, Brinda R; Slack, Rebecca S; Vence, Luis; Emerson, Ryan O; Yusko, Erik; Vignali, Marissa; Robins, Harlan S; Sun, Jingjing; Allison, James P; Sharma, Padmanee.
Afiliação
  • Subudhi SK; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Aparicio A; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Gao J; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Zurita AJ; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Araujo JC; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Logothetis CJ; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Tahir SA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Korivi BR; Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Slack RS; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Vence L; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Emerson RO; Adaptive Biotechnologies, Seattle, WA 98102.
  • Yusko E; Adaptive Biotechnologies, Seattle, WA 98102.
  • Vignali M; Adaptive Biotechnologies, Seattle, WA 98102.
  • Robins HS; Adaptive Biotechnologies, Seattle, WA 98102; Fred Hutchinson Cancer Research Center, Seattle, WA 98102.
  • Sun J; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Allison JP; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 padsharma@mdanderson.org jallison@mdanderson.org.
  • Sharma P; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 7
Proc Natl Acad Sci U S A ; 113(42): 11919-11924, 2016 10 18.
Article em En | MEDLINE | ID: mdl-27698113

Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Contagem de Linfócitos / Linfócitos T CD8-Positivos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Evolução Clonal / Ipilimumab / Antineoplásicos Imunológicos Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Contagem de Linfócitos / Linfócitos T CD8-Positivos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Evolução Clonal / Ipilimumab / Antineoplásicos Imunológicos Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article