Smart nanoparticles with a detachable outer shell for maximized synergistic antitumor efficacy of therapeutics with varying physicochemical properties.

Yin, Tingjie; Liu, Jiyong; Zhao, Zekai; Dong, Lihui; Cai, Han; Yin, Lifang; Zhou, Jianping; Huo, Meirong

Yin, Tingjie; Liu, Jiyong; Zhao, Zekai; Dong, Lihui; Cai, Han; Yin, Lifang; Zhou, Jianping; Huo, Meirong.

Afiliação

Yin T; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Liu J; Department of Pharmacy, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Zhao Z; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Dong L; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Cai H; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Yin L; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Zhou J; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: cpu_zhoujp@163.com.
Huo M; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: huomeirongcpu@163.com.

J Control Release ; 243: 54-68, 2016 12 10.

Article em En | MEDLINE | ID: mdl-27702595

Assuntos

Antineoplásicos/administração & dosagem; Receptores de Hialuronatos/metabolismo; Ácido Hialurônico/química; Nanopartículas; Animais; Antineoplásicos/química; Antineoplásicos/farmacologia; Química Farmacêutica/métodos; Portadores de Fármacos/química; Sistemas de Liberação de Medicamentos; Sinergismo Farmacológico; Feminino; Humanos; Interações Hidrofóbicas e Hidrofílicas; Camundongos Endogâmicos BALB C; Camundongos Nus; Neoplasias/tratamento farmacológico; Neoplasias/patologia; Polietilenoimina/química; RNA Interferente Pequeno/administração & dosagem; Células THP-1; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Drug co-delivery; Nanoparticles; Self-assembly; Stimuli-responsive; Synergistic effect

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Hialuronatos / Nanopartículas / Ácido Hialurônico / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google