RORγt, a multitask nuclear receptor at mucosal surfaces.
Mucosal Immunol
; 10(1): 27-34, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27706126
ABSTRACT
RORγt is a nuclear hormone receptor that has followed an exponential success carrier. Its modest origins as an orphan receptor cloned from human pancreas blossomed within 15 years into a critical regulator of anti-microbial immunity and a major target in the fight against inflammatory pathologies. Here, I review its role as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses. RORγt is also an intriguing molecule that is regulated by the circadian rhythm and includes cholesterol metabolites as ligands. RORγt therefore links anti-microbial immunity with circadian rhythms and steroids, the logic of which remains to be understood.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
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Ativação Transcricional
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Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares
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Microbiota
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Hipersensibilidade
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Imunidade Inata
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Infecções
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article