Combined Effect of Low-Intensity Helium-Neon Laser and X-Ray Radiation on in Vivo Cellular Response of the Whole Blood and Lymphoid Organs in Mice.
Bull Exp Biol Med
; 161(5): 679-682, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27709381
ABSTRACT
We studied the effect of exposure to helium-neon laser (dose range 0.16-50 mJ/cm2) on activation of natural protection reserve in mice using the adaptive response test. DNA comets method revealed a protective response manifested in DNA damage level in whole blood leukocytes of mice and in lymphoid organs by the thymus and spleen weight index; preexposure to laser did not induce the adaptive response. ROS level in the whole blood was assessed by the level of zymosan-induced luminol chemiluminescence. In mice subjected to adaptive laser irradiation in doses of 0.16-5 mJ/cm2 followed by X-ray irradiation in a dose of 1.5 Gy, the activation index calculated as the ratio of induced to spontaneous area of luminescence was by 1.4 times lower than that in non-irradiated animals, which attested to reduced ROSgeneration reserve capacity of neutrophils.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Baço
/
Lasers de Gás
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article