Hemodynamic Control of Endothelial Cell Fates in Development.
Annu Rev Cell Dev Biol
; 32: 633-648, 2016 10 06.
Article
em En
| MEDLINE
| ID: mdl-27712101
ABSTRACT
Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. From the onset of blood flow, the embryonic vasculature is continuously exposed to a variety of hemodynamic forces. These biomechanical stimuli are key determinants of vascular cell specification and remodeling and the establishment of vascular homeostasis. In recent years, major advances have been made in our understanding of mechano-activated signaling networks that control both spatiotemporal and structural aspects of vascular development. It has become apparent that a major site for mechanotransduction is situated at the interface of blood and the vessel wall and that this process is controlled by the vascular endothelium. In this review, we discuss the hemodynamic control of endothelial cell fates, focusing on arterial-venous specification, lymphatic development, and the endothelial-to-hematopoietic transition, and present some recent insights into the mechano-activated pathways driving these cell fate decisions in the developing embryo.
Palavras-chave
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Linhagem da Célula
/
Células Endoteliais
/
Desenvolvimento Embrionário
/
Hemodinâmica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article