Synthesis of Substituted 2,3-Benzodiazepines.
J Org Chem
; 81(20): 9836-9847, 2016 10 21.
Article
em En
| MEDLINE
| ID: mdl-27715040
ABSTRACT
A new, four-step synthetic route for substituted 2,3-benzodiazepines 1, starting from aldehyde 4, was developed with excellent overall yields. This route included the 1,2-addition of various aromatic Grignard reagents to 4, PCC oxidation, and aerobic Wacker-type oxidation of the olefinic group of 6, followed by condensation of the resulting 1,5-dicarbonyl 7 with N2H4. Isoquinolones 9 were obtained when an aldehyde group was used instead of a ketone. The key structures were confirmed by X-ray single-crystal diffraction analysis.
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MEDLINE
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article