The Journey of Lipoproteins Through the Cell: One Birthplace, Multiple Destinations.
Adv Microb Physiol
; 69: 1-50, 2016.
Article
em En
| MEDLINE
| ID: mdl-27720009
Bacterial lipoproteins are a very diverse group of proteins characterized by the presence of an N-terminal lipid moiety that serves as a membrane anchor. Lipoproteins have a wide variety of crucial functions, ranging from envelope biogenesis to stress response. In Gram-negative bacteria, lipoproteins can be targeted to various destinations in the cell, including the periplasmic side of the cytoplasmic or outer membrane, the cell surface or the external milieu. The sorting mechanisms have been studied in detail in Escherichia coli, but exceptions to the rules established in this model bacterium exist in other bacteria. In this chapter, we will present the current knowledge on lipoprotein sorting in the cell. Our particular focus will be on the surface-exposed lipoproteins that appear to be much more common than previously assumed. We will discuss the different targeting strategies, provide numerous examples of surface-exposed lipoproteins and discuss the techniques used to assess their surface exposure.
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MEDLINE
Assunto principal:
Proteínas da Membrana Bacteriana Externa
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Processamento de Proteína Pós-Traducional
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Transporte Proteico
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Bactérias Gram-Negativas
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Lipoproteínas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article