Aqueous Chlorhexidine for Intravitreal Injection Antisepsis: A Case Series and Review of the Literature.
Ophthalmology
; 123(12): 2588-2594, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27720552
ABSTRACT
PURPOSE:
To determine the incidence of endophthalmitis in a large clinical series using aqueous chlorhexidine for antisepsis before intravitreal injection and to review the ophthalmic literature regarding chlorhexidine efficacy and safety.DESIGN:
Multicenter retrospective case series.PARTICIPANTS:
All patients receiving intravitreal injections from 7 retinal specialists.METHODS:
An audit of intravitreal injections performed by retinal specialists who exclusively used aqueous chlorhexidine 0.05% or 0.1% for prophylaxis of infective endophthalmitis was undertaken. The incidence of endophthalmitis was determined from August 1, 2011, to February 28, 2015. A literature review was performed to critically appraise the ocular safety and efficacy of aqueous chlorhexidine. MAIN OUTCOMEMEASURES:
Incidence of endophthalmitis after intravitreal injections.RESULTS:
A total of 40 535 intravitreal injections were performed by 7 retinal specialists across 3 centers. Chlorhexidine was well tolerated, and only 1 patient with a suspected allergic reaction was noted. Three cases of endophthalmitis were identified with 1 culture-positive case. The 0.0074% (1 in 13 512) per-injection rate of endophthalmitis in this series compares favorably with previous series in which povidone-iodine has been used.CONCLUSIONS:
Aqueous chlorhexidine was associated with a low rate of postinjection endophthalmitis and was well tolerated by patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Oculares Bacterianas
/
Clorexidina
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Endoftalmite
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Injeções Intravítreas
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Anti-Infecciosos Locais
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article