Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCß2.

Miao, Wei; Wu, Xiujuan; Wang, Kang; Wang, Wenjing; Wang, Yumei; Li, Zhigang; Liu, Jingjing; Li, Li; Peng, Luying

Miao, Wei; Wu, Xiujuan; Wang, Kang; Wang, Wenjing; Wang, Yumei; Li, Zhigang; Liu, Jingjing; Li, Li; Peng, Luying.

Afiliação

Miao W; Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. wikimiao@126.com.
Wu X; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. wikimiao@126.com.
Wang K; Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China. wikimiao@126.com.
Wang W; Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. wuxiujuan1992@163.com.
Wang Y; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. wuxiujuan1992@163.com.
Li Z; Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China. wuxiujuan1992@163.com.
Liu J; Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. tongji_wk@163.com.
Li L; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. tongji_wk@163.com.
Peng L; Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China. tongji_wk@163.com.

Int J Mol Sci ; 17(10)2016 Oct 10.

Article em En | MEDLINE | ID: mdl-27735862

Assuntos

Ácido Butírico/farmacologia; Miosinas Cardíacas/metabolismo; Cadeias Leves de Miosina/metabolismo; Quinase de Cadeia Leve de Miosina/metabolismo; Proteína Quinase C beta/metabolismo; Junções Íntimas/efeitos dos fármacos; Proteínas Quinases Ativadas por AMP/metabolismo; Western Blotting; Células CACO-2; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/metabolismo; Miosinas Cardíacas/antagonistas & inibidores; Humanos; Imunoprecipitação; Cadeias Leves de Miosina/antagonistas & inibidores; Quinase de Cadeia Leve de Miosina/antagonistas & inibidores; Fosforilação/efeitos dos fármacos; Junções Íntimas/metabolismo

Palavras-chave

(protein kinase C ß) PKCß; Caco-2; butyrate; myosin II regulatory light chain (MLC2); myosin light chain kinase (MLCK); tight junction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinase de Cadeia Leve de Miosina / Junções Íntimas / Cadeias Leves de Miosina / Ácido Butírico / Miosinas Cardíacas / Proteína Quinase C beta Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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