Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery.

Kumar, Pardeep; Kuhlmann, F Matthew; Bhullar, Kirandeep; Yang, Hyungjun; Vallance, Bruce A; Xia, Lijun; Luo, Qingwei; Fleckenstein, James M

Kumar, Pardeep; Kuhlmann, F Matthew; Bhullar, Kirandeep; Yang, Hyungjun; Vallance, Bruce A; Xia, Lijun; Luo, Qingwei; Fleckenstein, James M.

Afiliação

Kumar P; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Kuhlmann FM; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Bhullar K; Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada.
Yang H; Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada.
Vallance BA; Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada.
Xia L; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Luo Q; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Fleckenstein JM; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA jflecken@wustl.edu.

Infect Immun ; 84(12): 3608-3617, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27736776

Assuntos

Adesinas Bacterianas/metabolismo; Escherichia coli Enterotoxigênica/fisiologia; Mucosa Intestinal/microbiologia; Mucinas/metabolismo; Acetilgalactosamina/metabolismo; Adesinas Bacterianas/genética; Animais; Células CACO-2; Escherichia coli Enterotoxigênica/genética; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Células HT29; Humanos; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mucina-2/genética; Mucina-2/metabolismo; Interferência de RNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adesinas Bacterianas / Escherichia coli Enterotoxigênica / Mucosa Intestinal / Mucinas Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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