Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage.
J Enzyme Inhib Med Chem
; 32(1): 5-12, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-27766895
ABSTRACT
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the α-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton. Despite these two enzymes share a 49% sequence identity and present a very similar three-dimensional structure, they show profound differences when comparing the specific activity for CO2 hydration reaction, with CA VII being much more active than CA III. Recently, CA III and CA VII have been proposed to play a new role as scavenger enzymes in cells where oxidative damage occurs. Here, we will examine functional and structural features of these two isoforms giving insights into their newly proposed protective role against oxidative stress.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
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Anidrases Carbônicas
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Estresse Oxidativo
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article