Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele.
Hum Genet
; 83(2): 119-21, 1989 Sep.
Article
em En
| MEDLINE
| ID: mdl-2777251
ABSTRACT
Genotyping of mitochondrial aldehyde dehydrogenase (ALDH I) was performed in enzymatically amplified DNA of 20 Chinese, Japanese and South Korean families (85 individuals) and in 113 unrelated persons by employing allele-specific oligonucleotide probes and dot blot hybridization. Genotyping individuals with phenotypic deficiency of ALDH I activity always showed the presence of at least one mutant allele. The data are compatible with a model assuming dominant inheritance of the mutant allele, which we have previously suggested on the basis of a population study.
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Base de dados:
MEDLINE
Assunto principal:
Aldeído Desidrogenase
/
Alelos
/
Genes Dominantes
/
Mitocôndrias
/
Mutação
Limite:
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article