Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction.
Biomarkers
; 22(3-4): 304-310, 2017.
Article
em En
| MEDLINE
| ID: mdl-27775442
ABSTRACT
CONTEXT Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes. OBJECTIVE:
The study examined the early release kinetics of TnTuORF. MATERIALS ANDMETHODS:
We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n = 31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH).RESULTS:
Fifteen minutes after TASH, the levels of both troponins increased significantly (cTnT median 18 ng/L versus 27 ng/L; cTnI median 15 ng/L versus 25 ng/L). TnTuORF showed no variation.DISCUSSION:
We observed a significantly greater increase in cTnI compared with cTnT.CONCLUSION:
Our results demonstrate that troponin assays allow early detection of myocardial injury, whereas TnTuORF levels remain unchanged in this setting.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Cardiomiopatia Hipertrófica
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Troponina I
/
Troponina T
/
Infarto do Miocárdio
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article