Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers.

Kamiguchi, Hidenori; Murabayashi, Mika; Mori, Ikuo; Horinouchi, Akira; Higaki, Kazutaka

Kamiguchi, Hidenori; Murabayashi, Mika; Mori, Ikuo; Horinouchi, Akira; Higaki, Kazutaka.

Afiliação

Kamiguchi H; a Integrated Technology Research Laboratories , Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Kanagawa , Japan.
Murabayashi M; b Process Chemistry, Pharmaceutical Science , Takeda Pharmaceutical Company Limited , Osaka , Japan.
Mori I; a Integrated Technology Research Laboratories , Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Kanagawa , Japan.
Horinouchi A; c PS Administration Department, Pharmaceutical Science , Takeda Pharmaceutical Company Limited , Osaka , Japan.
Higaki K; d Department of Pharmaceutics, Faculty of Pharmaceutical Sciences , Okayama University , Okayama , Japan.

Biomarkers ; 22(2): 178-188, 2017 Mar.

Article em En | MEDLINE | ID: mdl-27775443

Assuntos

Biomarcadores/análise; Glicina/análogos & derivados; Hipuratos/análise; Lipidoses/diagnóstico; Animais; Biomarcadores/sangue; Biomarcadores/urina; Monitoramento de Medicamentos/métodos; Glicina/análise; Glicina/sangue; Glicina/urina; Hipuratos/sangue; Hipuratos/urina; Lipidoses/induzido quimicamente; Metabolômica/métodos; Fosfolipídeos; Ratos

Palavras-chave

Phenylacetylglycine; drug-induced phospholipidosis; hippuric acid; phenylalanine metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Glicina / Hipuratos / Lipidoses Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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