Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck.
Head Neck
; 39(3): 456-463, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27775851
ABSTRACT
BACKGROUND:
We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease.METHODS:
A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed.RESULTS:
Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases.CONCLUSION:
Metastatic ACC is not always an indolent disease. © 2016 Wiley Periodicals, Inc. Head Neck 39 456-463, 2017.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Causas de Morte
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Carcinoma Adenoide Cístico
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Neoplasias de Cabeça e Pescoço
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Linfonodos
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article