Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo.
Surgery
; 161(3): 735-746, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27776794
ABSTRACT
BACKGROUND:
Interleukin-15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate cells of the innate and adaptive immune system.METHODS:
We generated an interleukin-15-expressing oncolytic influenza A virus for the treatment of an established murine tumor model.RESULTS:
Our oncolytic influenza A virus produced large amounts of interleukin-15 and induced proliferation and activation of human T cells in vitro. Intraperitoneal administration increased the amount of mouse natural killer cells and effector memory T cells, as well as T cell reactivity in vivo. Moreover, intratumoral injection induced a profound decrease in growth of established tumors in mice and increased the amount of tumor-infiltrating T cells and natural killer cells.CONCLUSION:
We established a stable, IL-15-producing oncolytic influenza A virus with promising immunostimulatory and antitumor attributes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Neoplasias Cutâneas
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Melanoma Experimental
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Interleucina-15
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Vírus Oncolíticos
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Terapia Viral Oncolítica
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article