Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis.

Michailidou, Iliana; Naessens, Daphne M P; Hametner, Simon; Guldenaar, Willemijn; Kooi, Evert-Jan; Geurts, Jeroen J G; Baas, Frank; Lassmann, Hans; Ramaglia, Valeria

Michailidou, Iliana; Naessens, Daphne M P; Hametner, Simon; Guldenaar, Willemijn; Kooi, Evert-Jan; Geurts, Jeroen J G; Baas, Frank; Lassmann, Hans; Ramaglia, Valeria.

Afiliação

Michailidou I; Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105, The Netherlands.
Naessens DM; Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105, The Netherlands.
Hametner S; Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, Vienna, 1090, Austria.
Guldenaar W; Department of Anatomy and Neurosciences, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081, The Netherlands.
Kooi EJ; Department of Anatomy and Neurosciences, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081, The Netherlands.
Geurts JJ; Department of Anatomy and Neurosciences, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081, The Netherlands.
Baas F; Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105, The Netherlands.
Lassmann H; Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, Vienna, 1090, Austria.
Ramaglia V; Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105, The Netherlands.

Glia ; 65(2): 264-277, 2017 02.

Article em En | MEDLINE | ID: mdl-27778395

Assuntos

Complemento C3/metabolismo; Microglia/metabolismo; Esclerose Múltipla/patologia; Doença Aguda; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Autopsia; Proteínas de Ligação ao Cálcio; Doença Crônica; Complemento C3/genética; Citocinas/metabolismo; Proteínas de Ligação a DNA/metabolismo; Modelos Animais de Doenças; Feminino; Traumatismos Cranianos Fechados/patologia; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Proteínas dos Microfilamentos; Pessoa de Meia-Idade; Proteínas da Mielina/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Neurônios/patologia; Acidente Vascular Cerebral/patologia

Palavras-chave

lesions; microglia; pathology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C3 / Microglia / Esclerose Múltipla Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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