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Chimpanzee genomic diversity reveals ancient admixture with bonobos.
de Manuel, Marc; Kuhlwilm, Martin; Frandsen, Peter; Sousa, Vitor C; Desai, Tariq; Prado-Martinez, Javier; Hernandez-Rodriguez, Jessica; Dupanloup, Isabelle; Lao, Oscar; Hallast, Pille; Schmidt, Joshua M; Heredia-Genestar, José María; Benazzo, Andrea; Barbujani, Guido; Peter, Benjamin M; Kuderna, Lukas F K; Casals, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe; Kühl, Hjalmar; Vigilant, Linda; Langergraber, Kevin; Novembre, John; Gut, Marta; Gut, Ivo; Navarro, Arcadi; Carlsen, Frands; Andrés, Aida M; Siegismund, Hans R; Scally, Aylwyn; Excoffier, Laurent; Tyler-Smith, Chris; Castellano, Sergi; Xue, Yali; Hvilsom, Christina; Marques-Bonet, Tomas.
Afiliação
  • de Manuel M; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Kuhlwilm M; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Frandsen P; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark. Center for Zoo and Wild Animal Health, Copenhagen Zoo, 2000 Frederiksberg, Denmark.
  • Sousa VC; Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Desai T; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Prado-Martinez J; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Hernandez-Rodriguez J; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Dupanloup I; Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Lao O; National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Hallast P; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
  • Schmidt JM; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103, Leipzig, Germany.
  • Heredia-Genestar JM; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Benazzo A; Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.
  • Barbujani G; Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.
  • Peter BM; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Kuderna LF; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Casals F; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.
  • Angedakin S; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
  • Arandjelovic M; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
  • Boesch C; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
  • Kühl H; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
  • Vigilant L; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
  • Langergraber K; School of Human Evolution and Social Change and Institute of Human Origins, Arizona State University, Tempe, AZ 85287, USA.
  • Novembre J; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  • Gut M; National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  • Gut I; National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  • Navarro A; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain. National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and
  • Carlsen F; Center for Zoo and Wild Animal Health, Copenhagen Zoo, 2000 Frederiksberg, Denmark.
  • Andrés AM; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103, Leipzig, Germany.
  • Siegismund HR; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Scally A; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Excoffier L; Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  • Tyler-Smith C; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Castellano S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103, Leipzig, Germany.
  • Xue Y; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  • Hvilsom C; Center for Zoo and Wild Animal Health, Copenhagen Zoo, 2000 Frederiksberg, Denmark. ch@zoo.dk tomas.marques@upf.edu.
  • Marques-Bonet T; Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain. National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and
Science ; 354(6311): 477-481, 2016 10 28.
Article em En | MEDLINE | ID: mdl-27789843
ABSTRACT
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Pan troglodytes / Evolução Molecular / Pan paniscus Tipo de estudo: Prognostic_studies Limite: Animals País como assunto: Africa Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Pan troglodytes / Evolução Molecular / Pan paniscus Tipo de estudo: Prognostic_studies Limite: Animals País como assunto: Africa Idioma: En Ano de publicação: 2016 Tipo de documento: Article