Characterization of an epoxide-derived metabolite of dictamnine using high-performance liquid chromatography with hybrid linear trap quadrupole orbitrap mass spectrometry.

Feng, Pinning; Hu, Xinrong; Wu, Xiaoliang; Dong, Jun; Cai, Xiuyu

Feng, Pinning; Hu, Xinrong; Wu, Xiaoliang; Dong, Jun; Cai, Xiuyu.

Afiliação

Feng P; Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China.
Hu X; Department of oncology, Nanxi Mountain hospital, Guilin, P. R. China.
Wu X; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China.
Dong J; Department of General Internal Medicine, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.
Cai X; Department of General Internal Medicine, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.

J Sep Sci ; 39(24): 4858-4865, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27790853

Assuntos

Cromatografia Líquida de Alta Pressão; Espectrometria de Massas; Quinolinas/análise; Animais; Bile/química; Compostos de Epóxi; Quinolinas/urina; Ratos

Palavras-chave

Dictamnine; Metabolic activation; N-acetylcysteine conjugates; Reactive metabolites; Toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Espectrometria de Massas / Cromatografia Líquida de Alta Pressão Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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