Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters.
Adv Healthc Mater
; 5(23): 3067-3073, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27792296
ABSTRACT
To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site-specific way using original hybrid silylated antibacterial peptides. This safe and up-scalable method guarantees a covalent and robust immobilization with the correct orientation of the bioactive moiety. Importantly it also avoids multi-step chemical modifications of the surface or multi-layer polymer coatings. As proof of concept, antibacterial silicone catheter has been prepared whose immediate and long term efficiency is superior by comparison to similar silver-embedded materials.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Silicones
/
Antibacterianos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article