In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.
Neurology
; 87(22): 2309-2316, 2016 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-27794115
ABSTRACT
OBJECTIVE:
To determine whether 18F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS).METHODS:
We evaluated the in vitro binding of 3H-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies, 18F-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD).RESULTS:
3H-THK5351 was able to bind to tau deposits in the postmortem brain with CBD. In clinical PET studies, the 5 patients with CBS showed significantly higher 18F-THK5351 retention in the frontal, parietal, and globus pallidus than the 8 age-matched normal controls and patients with AD. Higher 18F-THK5351 retention was observed contralaterally to the side associated with greater cortical dysfunction and parkinsonism.CONCLUSIONS:
18F-THK5351 PET demonstrated high tracer signal in sites susceptible to tau deposition in patients with CBS. 18F-THK5351 should be considered as a promising candidate radiotracer for the in vivo imaging of tau deposits in CBS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Gânglios da Base
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Encéfalo
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Proteínas tau
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Tomografia por Emissão de Pósitrons
Tipo de estudo:
Diagnostic_studies
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Evaluation_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article