Acetophenone Monomers from Acronychia trifoliolata.
J Nat Prod
; 79(11): 2883-2889, 2016 11 23.
Article
em En
| MEDLINE
| ID: mdl-27797192
ABSTRACT
Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH3OH/CH2Cl2 (11) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetofenonas
/
Rutaceae
/
Antineoplásicos Fitogênicos
Limite:
Humans
País como assunto:
America do norte
/
Asia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article