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Men's health supplement use and outcomes in men receiving definitive intensity-modulated radiation therapy for localized prostate cancer.
Zaorsky, Nicholas G; Churilla, Thomas M; Ruth, Karen; Hayes, Shelly B; Sobczak, Mark L; Hallman, Mark A; Smaldone, Marc C; Chen, David Yt; Horwitz, Eric M.
Afiliação
  • Zaorsky NG; Department of Radiation Oncology, nicholaszaorsky@gmail.com.
  • Churilla TM; Department of Radiation Oncology.
  • Ruth K; Biostatistics and Bioinformatics Facility, and.
  • Hayes SB; Department of Radiation Oncology.
  • Sobczak ML; Department of Radiation Oncology.
  • Hallman MA; Department of Radiation Oncology.
  • Smaldone MC; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
  • Chen DY; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
  • Horwitz EM; Department of Radiation Oncology.
Am J Clin Nutr ; 104(6): 1583-1593, 2016 12.
Article em En | MEDLINE | ID: mdl-27797706
ABSTRACT

BACKGROUND:

Approximately 50% of newly diagnosed cancer patients start taking dietary supplements. Men's health supplements (MHSs), which we define as supplements that are specifically marketed with the terms men's health and prostate health (or similar permutations), are often mislabeled as having potential anticancer benefits.

OBJECTIVE:

We evaluated the effects of MHSs on patient outcomes and toxicities in patients who were undergoing definitive intensity-modulated radiation therapy (IMRT) for localized prostate cancer.

DESIGN:

This retrospective analysis included patients who were being treated at a National Cancer Institute-designated comprehensive cancer center and consented to have information stored in a prospective database. MHSs were queried online. Outcome measures were freedom from biochemical failure (FFBF) (biochemical failure was defined with the use of the prostate-specific antigen nadir + 2-ng/mL definition), freedom from distant metastasis (FFDM), cancer-specific survival (CSS), and overall survival (OS) as well as toxicities. Kaplan-Meier analysis, log-rank tests, Fine and Gray competing-risk regression (to adjust for patient and lifestyle factors), and Cox models were used.

RESULTS:

From 2001 to 2012, 2207 patients were treated with IMRT with a median dose of 78 Gy, and a median follow-up of 46 mo. Of these patients, 43% were low risk, 37% were intermediate risk, and 20% were high risk; 10% used MHSs. MHSs contained a median of 3 identifiable ingredients (range 0-78 ingredients). Patients who were taking an MHS compared with those who were not had improved 5-y OS (97% compared with 92%, respectively; P = 0.01), but there were no differences in the FFBF (94% compared with 89%, respectively; P = 0.12), FFDM (96% compared with 97%, respectively; P = 0.32), or CSS (100% compared with 99%, respectively; P = 0.22). The unadjusted association between MHS use and improved OS was attenuated after adjustment for patient lifestyle factors and comorbidities. There was no difference in toxicities between the 2 groups (late-grade 3-4 genitourinary <3%; gastrointestinal <4%).

CONCLUSION:

The use of MHSs is not associated with outcomes or toxicities.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Micronutrientes / Suplementos Nutricionais / Radioterapia de Intensidade Modulada / Saúde do Homem Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Micronutrientes / Suplementos Nutricionais / Radioterapia de Intensidade Modulada / Saúde do Homem Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article