Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain - Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis.

Rogers, Michelle L; Leong, Chi Leng; Gowers, Sally An; Samper, Isabelle C; Jewell, Sharon L; Khan, Asma; McCarthy, Leanne; Pahl, Clemens; Tolias, Christos M; Walsh, Daniel C; Strong, Anthony J; Boutelle, Martyn G

Rogers, Michelle L; Leong, Chi Leng; Gowers, Sally An; Samper, Isabelle C; Jewell, Sharon L; Khan, Asma; McCarthy, Leanne; Pahl, Clemens; Tolias, Christos M; Walsh, Daniel C; Strong, Anthony J; Boutelle, Martyn G.

Afiliação

Rogers ML; 1 Department of Bioengineering, Imperial College, London, UK.
Leong CL; 1 Department of Bioengineering, Imperial College, London, UK.
Gowers SA; 1 Department of Bioengineering, Imperial College, London, UK.
Samper IC; 1 Department of Bioengineering, Imperial College, London, UK.
Jewell SL; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.
Khan A; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.
McCarthy L; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.
Pahl C; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.
Tolias CM; 3 King's College Hospital NHS Foundation Trust, London, UK.
Walsh DC; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.
Strong AJ; 3 King's College Hospital NHS Foundation Trust, London, UK.
Boutelle MG; 2 Department of Basic and Clinical Neuroscience, King's College, London, UK.

J Cereb Blood Flow Metab ; 37(5): 1883-1895, 2017 May.

Article em En | MEDLINE | ID: mdl-27798268

Assuntos

Lesões Encefálicas/fisiopatologia; Depressão Alastrante da Atividade Elétrica Cortical/fisiologia; Glucose/metabolismo; Ácido Láctico/metabolismo; Microdiálise; Monitorização Neurofisiológica/métodos; Potássio/metabolismo; Lesões Encefálicas/metabolismo; Coma/metabolismo; Coma/fisiopatologia; Eletrocorticografia; Humanos; Sistemas On-Line

Palavras-chave

On-line microdialysis; ischaemic brain injury; microfluidics; neurometabolic coupling; spreading depolarization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Potássio / Depressão Alastrante da Atividade Elétrica Cortical / Lesões Encefálicas / Microdiálise / Ácido Láctico / Monitorização Neurofisiológica / Glucose Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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