In vivo Patterns of Tau Pathology, Amyloid-ß Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.
J Alzheimers Dis
; 55(2): 465-471, 2017.
Article
em En
| MEDLINE
| ID: mdl-27802224
ABSTRACT
The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-ß. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-ß deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Peptídeos beta-Amiloides
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Proteínas tau
/
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article