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A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems.
Xu, Jiaxi; Mukerjee, Snigdha; Silva-Alves, Cristiane R A; Carvalho-Galvão, Alynne; Cruz, Josiane C; Balarini, Camille M; Braga, Valdir A; Lazartigues, Eric; França-Silva, Maria S.
Afiliação
  • Xu J; Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
  • Mukerjee S; Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
  • Silva-Alves CR; Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
  • Carvalho-Galvão A; Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
  • Cruz JC; Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
  • Balarini CM; Centro de Ciências da Saúde, Universidade Federal da Paraíba João Pessoa, Brazil.
  • Braga VA; Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
  • Lazartigues E; Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center New Orleans, LA, USA.
  • França-Silva MS; Centro de Biotecnologia, Universidade Federal da Paraíba João Pessoa, Brazil.
Front Physiol ; 7: 469, 2016.
Article em En | MEDLINE | ID: mdl-27803674
ABSTRACT
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article