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Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Hemmerling, Martin; Edman, Karl; Lepistö, Matti; Eriksson, Anders; Ivanova, Svetlana; Dahmén, Jan; Rehwinkel, Hartmut; Berger, Markus; Hendrickx, Ramon; Dearman, Matthew; Jensen, Tina Jellesmark; Wissler, Lisa; Hansson, Thomas.
Afiliação
  • Hemmerling M; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden. Electronic address: martin.hemmerling@astrazeneca.com.
  • Edman K; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 431 83, Sweden.
  • Lepistö M; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
  • Eriksson A; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
  • Ivanova S; AstraZeneca R&D Lund, Scheelevägen 1, Lund 22187, Sweden.
  • Dahmén J; AstraZeneca R&D Lund, Scheelevägen 1, Lund 22187, Sweden.
  • Rehwinkel H; Medicinal Chemistry Berlin, Candidate Generation & External Innovation, Drug Discovery, Bayer Pharma AG, Berlin 13353, Germany.
  • Berger M; Medicinal Chemistry Berlin, Candidate Generation & External Innovation, Drug Discovery, Bayer Pharma AG, Berlin 13353, Germany.
  • Hendrickx R; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
  • Dearman M; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
  • Jensen TJ; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
  • Wissler L; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 431 83, Sweden.
  • Hansson T; Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
Bioorg Med Chem Lett ; 26(23): 5741-5748, 2016 12 01.
Article em En | MEDLINE | ID: mdl-27810243
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Anti-Inflamatórios não Esteroides / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Anti-Inflamatórios não Esteroides / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article