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Baicalin, a natural LSD1 inhibitor.
Zheng, Yi-Chao; Shen, Dan-Dan; Ren, Meng; Liu, Xue-Qi; Wang, Zhi-Ru; Liu, Ying; Zhang, Qian-Na; Zhao, Li-Juan; Zhao, Li-Jie; Ma, Jin-Lian; Yu, Bin; Liu, Hong-Min.
Afiliação
  • Zheng YC; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Shen DD; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Ren M; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Liu XQ; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Wang ZR; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Liu Y; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Zhang QN; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Zhao LJ; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Zhao LJ; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Ma JL; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Yu B; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
  • Liu HM; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Z
Bioorg Chem ; 69: 129-131, 2016 12.
Article em En | MEDLINE | ID: mdl-27814566
ABSTRACT
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01µM and showed strong LSD1 inhibitory effect in cells. Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Produtos Biológicos / Inibidores Enzimáticos / Histona Desmetilases Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Produtos Biológicos / Inibidores Enzimáticos / Histona Desmetilases Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article