Baicalin, a natural LSD1 inhibitor.
Bioorg Chem
; 69: 129-131, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27814566
ABSTRACT
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01µM and showed strong LSD1 inhibitory effect in cells. Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Produtos Biológicos
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Inibidores Enzimáticos
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Histona Desmetilases
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article